In meeting the stringent emission norms the injector selection plays a vital role. Selection of optimum injection parameters helps in achieving good spray targeting and efficient atomization of fuel to generate optimum mixing effect. The purpose of this experimental study is to investigate the effect of injection parameters on a heavy duty diesel engine performance and emission characteristics. The injection parameters such as hydraulic through flow, cone angle, number of holes & hole diameter are studied on 6-cylinder turbocharged common rail diesel engine (BS-IV). The influence of these parameters and their combinations along with the various injection strategies are analyzed using different parametric variations in order to see the combustion and performance trend of engine. The performance of the various hardware configurations are then evaluated and discussed based on the fuel consumption and exhaust emission values.