In order to predict the interior noise of a commercial vehicle cab, a finite element model of a heavy commercial vehicle cab was established. An acoustic-structure coupling model of the cab was built based on experimentally validated structure model and acoustic model of a commercial vehicle cab. Moreover, based on the platform of Virtual. Lab, the acoustic field modes of the acoustic model of the commercial vehicle cab and the coupled modes of the acoustic-structure coupling model were analyzed by using the acoustic-structure coupling analysis technique. The excitation of the vehicle cab was tested at an average speed on an asphalt road. Then, the interior noise of the heavy commercial vehicle cab was predicted based on FEM-FEM method and FEM-BEM method with all the parameters and excitation. Furthermore, the predicted interior noise of the commercial vehicle cab was compared with the tested interior noise. The comparison showed that FEM-BEM method was more efficient than FEM-FEM method to predict the interior noise of the commercial vehicle cab.