The durability performance of brake hoses is a crucial issue for such components. Accelerated fatigue testing of brake hoses is necessary for understanding achievable lifetime, actually computation of durability is quite cumbersome due to the many different materials the hoses are made from. Despite SAE standards are available, accelerated testing of brake hoses subject to actual torsional and bending stresses seem important to provide relevant feedback to designers. In this paper, an innovative methodology for assessing the fatigue behavior of brake hoses of road vehicles is proposed. A dynamic testbed is specifically designed and realized, able to reproduce the actual assembly conditions of the hoses fitted into a vehicle suspension. The designed testbed allows to replicate actual loading conditions on the brake hoses by simulating the vertical dynamics and steering of the suspension system together with brake pressure. A procedure to extract the relevant loading cycles for damage is proposed and applied. The tests performed by exploiting the new testbed are in good agreement with the reported lifetimes of actual brake hoses fitted into test vehicles.