The control strategy design of vehicle active noise control (ANC) relies too much on experiment experience, which costs a lot to gather mass data and the experimental results lack representation. To solve these problems, a new control strategy optimization method based on the genetic algorithm is proposed. First, a vehicle cabin sound field simulation model is built by sound transfer function. Based on the filtered-X Least Mean Squares (FX-LMS) algorithm and the vehicle cabin sound field simulation model, a vehicle ANC simulation model is proposed and verified by a vehicle field test. Furthermore, the genetic algorithm is used as a strategy optimization tool to optimize an ANC control strategy parameter set based on the vehicle ANC simulation model. The optimized results provide a reference for the ANC control strategy design of the vehicle.