The advent of accuracy improvement methods in robotic arm manipulators have allowed these systems to penetrate applications previously reserved for larger, robustly supported machine architectures. A benefit of the relative reduced size of serial-link robotic systems is the potential for their mobilization throughout a manufacturing environment. However, the mobility of a system offers unique challenges in maintaining the high-accuracy requirement of many applications, particularly in aerospace manufacturing. Discussed herein are several aspects of mechanical design, control, and accuracy calibration required to retain accurate motion over large volumes when utilizing mobile articulated robotic systems. A number of mobile robot system architectures and their measured static accuracy performance are provided in support of the particular methods discussed.