IoT (Internet of things) is considered most innovative technology in smart healthcare monitoring system which is able to show real-time physiological parameters feed data to web cloud, analysis using machine learning, artificial intelligence and big data. Stroke is most deadly diseases and real-time monitoring is desired to detect stroke onset during regular activities. The aim of our study is to develop a Real-time health monitoring system for elderly drivers using air cushion seat and IoT devices in order to detect stroke onset during driving. We have also made a prototype of brain stroke detection system using Quad-chamber air cushion system and IoT devices. This system can measure ECG, EEG, heart rate, seat pressure balance data, face/eye tracking etc. using IoT sensors, compare real-time data with reference data, predict abnormality, generate alarm and send message to relatives and emergency services if any stroke onset happens in order to provide emergency assistance to driver.