In order to improve the comprehensive protection for children with variable shapes and sizes, this paper conducted studies on the impact injury for obese children based on a 10-YO finite element model. Some specific geometrics on the body surface were firstly acquired by the combination of pediatric anthropometric database and generator of body (GEBOD). A Radial Basis Function (RBF) based mesh morphing technique was then used to modify the original standard size FE model using the obtained geometrics. The morphed FE model was validated based on the experimental data of frontal sled test and chest-abdomen impact test. The effects of obesity on injury performances were analyzed through simplified high-speed and low-speed crash simulations.