Collaborative optimization is an important design tool in complex vehicle system engineering. However, there are many problems yet to be resolved when applying the conventional collaborative optimization method in vehicle body weight reduction, such as convergence difficulties and low optimization efficiency. To solve these problems, a maximum incompatibility constrained collaborative optimization method is proposed in the paper. First, the 1-norm equality constraints expression of the system level is used to replace the traditional 2-norm inequality constraints. Then, a maximum incompatibility is selected from modified inequality constraints to improve optimization efficiency. Finally, an overall compatibility constraint is introduced to decrease the influence caused by the initial point. A mathematical example is used to verify the effectiveness and stability of the proposed method. The proposed collaborative optimization method is further demonstrated through a vehicle body weight reduction problem concerning vehicle safety and NVH performances.