With the objective of minimizing structural weight in future large launch vehicles, several applicable advanced structural analysis techniques, materials, and unique approaches to structural design are assessed. Advanced structural design analysis techniques such as pressure coupling effects and higher allowable stresses by use of various biaxial stress field failure theories are considered. Each new technology or approach is individually applied to a representative vehicle. Structural weights with and without the new technology or approach are compared. The results may be used to assess the relative potential of each new technology as applied to possible future large launch vehicles.