This paper presents preliminary results of a study aimed at specification, selection and preliminary design of subsystems required to transform maneuvering, reentry body technology into a piloted, high performance Spaceplane, potentially capable of operating throughout cislunar space. This study, under contract to the U.S. Air Force, is being conducted by SRI-International, Hamilton Standard and several other aerospace contractors. Potential Spaceplane applications include placement, support, servicing and retrieval of satellites, and a variety of other military missions. The emphasis in this paper is on key issues relating to integration of the crewman into the vehicle. Issues discussed include environmental control/life support, cabin and spacesuit pressure levels and methods of heat rejection. Human factors issues relating to displays and controls, and prevention of the bends are also presented. Finally, major Spaceplane integration issues, such as center-of-gravity control, and payload and recovery system location are also addressed.