This paper contains an explanation of a Multiplex Wiring System with Optical Data-Link for cars, which has been installed in the Toyota “Century” since 1982. In this system, a total of 64 signals related to door wiring are transmitted in a multiplex fashion, and the number of wires from the front right-hand door to the interior could be reduced from 46 wires, which were used with conventional wiring techniques, to 10 wires including 2 plastic optical fibers. This system also has various control functions which includes a door-lock control function. In order to give high reliability to this system, we have developed a new optical data-link as well as a new custom micro-computer. And in the automobile industry, such a large scale multiplex wiring system having high reliability is very innovative in our opinion and will surely have a large impact in the future.