NASA's confidence in the flight readiness of aerospace hardware and software is achieved by a thorough integration of safety activities into every program facet, from concept through the mission. This involves technical and administrative personnel, organizations that specify requirements, design, manufacturing, test and the operators. Reviews by inhouse and external specialists form an integral part of the assurance process. Examples of safety issues and their resolution for some power and propulsion functions are given (lithium cells, autoignition/fretting in high pressure oxygen environments, ignition sources from auxiliary power unit, and low thrust rocket engines). Finally, some comments on NASA's integrated safety activities and the Aerospace Safety Advisory Panel's role in the NASA review and assessment process all of which provides added confidence in achieving a high level of mission safety and success.