1984-01-01

Animal Inhalation Studies on the Effects of Exhaust Emissions From Internal Combustion Engines 845082

The effects of the total exhaust emission with its hundreds of different compounds and potential coergisms resulting therefrom, with special reference to a potential carcinogenic or cocarcinogenic effect on the respiratory tract, can only be established using experiments which consider the exhaust with all its gaseous components and particulate matter as a whole.Long-term diesel and gasoline engine exhaust inhalatin studies with rats, hamsters and mice which have already been accomplished or are still running at the Fraunhofer-Institut für Toxikologie und Aerosolforschung, aim to investigate the chronic-toxic effects, as well as the potential carcinogencity or cocarcinogenicity of exhaust emissions.The combined effects of the exhaust gases with substances which have a known carcinogenic effect on the respiratory tract are integrated into a comprehensive experimental programme as is the investigation of diesel engine exhaust gases from which particulate matter has been removed using a centrifugal separator.A description of the complex experimental plant necessary for these experiments will be given and already existing test results will be explained and discussed.

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