A series of 500-hour duration tests were conducted using two medium-speed diesel engines to screen residual blended fuels for future locomotive field testing. The test fuels were railroad diesel fuel and two No. 6 fuel oil/diesel fuel blends. The performance, wear, fuel handling, and deposit characteristics of each fuel were evaluated. Combustion deposits, fuel handling, and wear were found to be the primary factors that limited No. 6 fuel oil content of blends. A 40 SSU viscosity blend was found to be acceptable for field trials, but a 55 SSU blend was not due to fuel filtration and combustion deposits problems.