This paper discusses techniques developed and used by the Biosciences Group at the University of Michigan Transportation Research Institute (UMTRI) for measuring three-dimensional head motion, skull bone strain, epidural pressure, and internal brain motion of repressurized cadavers and Rhesus monkeys during head impact. In the experimental design, a stationary test subject is struck by a guided moving impactor of 10 kg (monkeys) and 25 or 65 kg (cadavers). The impactor striking surface is fitted with padding to vary the contact force-time characteristics. The experimental technique uses a nine-accelerometer system rigidly affixed to the skull to measure head motion, transducers placed at specific points below the skull to record epidural pressure, repressurization of both the vascular and cerebrospinal systems, and high-speed cineradiography (at 1000 frames per second) of radiopaque targets. The results of several experimental tests imply intractable problems in determining potential injury criteria, such as the HIC, from accelerometer data.