Panel methods have become important aerodynamic prediction tools for aircraft design and analysis. To demonstrate the utility and accuracy of panel methods, three applications illustrating their usage are discussed in this paper. The computer code used is Lockheed's advanced low-order QUADrilateral element PANel method (QOADPAN). The first case presents correlation of force and moment predictions on a Lockheed P-3 Orion aircraft with rotodome for airborne early warning and control (AEW&C). The ability to predict incremental effects due to the rotodorae is demonstrated. The second application investigates the local flow behavior in the vicinity of the engine pylon and nacelle for a re-engined Boeing 727 derivative aircraft. Results include surface pressure distributions and the local flow characteristics using the flow-survey capability of QUADPAN. Finally, the third compares stability and rate derivative calculations for the Rockwell Space Shuttle atmospheric re-entry vehicle to wind tunnel and flight test data.