An experiment has been conducted to study the effect of vehicle alignment, tire construction and operational conditions on tire treadwear. The Taguchi approach was used to compose the experimental design and to analyze the data. The treadwear testing was conducted on the indoor test machine; this test duplicates the treadwear pattern observed during road test. The responses of interest were total wear, irregular wear patterns, and diagonal wear. The study quantified the relative importance of different factors to treadwear and also the degree of wear irregularity.