A major challenge facing the vehicle simulation test laboratory is correlating (and thereby validating) the simulated “test track” with the In-service environment. This simulation is key to the use of data for durability analysis from the integrated design and testing engineering process. Presented here is an approach to integrating road simulation test and fatigue life analysis that produces needed results for test, design and analysis engineers. The core of the analysis is a fatigue-based “rig-to-road” comparison for an on-highway vehicle using strain-time data acquired at fatigue sensitive locations. The cyclic and fatigue damaging content of the field and simulation profiles are compared quantitatively for purposes of validating the laboratory lest, and to illustrate a method of reporting this validation to design and analysis engineers.