This paper deals with the development and application of maintenance and serviceability-related design constraints during the design of the V-22 “Osprey” multi-service aircraft. The V-22 program has been unique in its early and continuous application of supportability emphasis during the aircraft development process. Integrated teams of logistics and design engineers were formed commencing with the beginning of the preliminary design phase to ensure maximum aircraft supportability. Mockups were used extensively to develop serviceability concepts and evaluate conceptual designs. Design approaches to enhance supportability were stressed throughout the development process. This paper highlights the effectiveness of the supportability enhancement process by reviewing the process itself and describing some of its resulting effects on the design of the “Osprey.” Because of the early and continuous emphasis on maintenance and serviceability during the V-22 design process, the V-22 “Osprey” will be the most supportable aircraft in its weight class in the Department of Defense inventory.