The Controlled Ecological Life Support System (CELSS) Emulator is operational for computer simulations of integrated CELSS operations involving humans, plants, process machinery, and reservoirs while the development of new capabilities continues. The Version 2.0 of the CELSS Emulator has been implemented to specify events, view data during model runs, generate data sets, store libraries of results for further analysis, and also display plots of model variables as a function of time. This paper describes a five-year simulation of two mission scenarios consisting of 14 different “events” that could take place at a lunar outpost. The time-dependent status of the life support consumables was calculated in response to the two selected mission scenarios. This application demonstrates that complex sequences of events are reproducible for understanding of integrated mission operations.