This paper presents two quite different solid amine carbon dioxide removal systems that have progressed to manned chamber testing status. The first is a carbon dioxide concentrator that was tested as part of a NASA sponsored 90 Day Manned Test in 1970. It provided a 99+% carbon dioxide stream for further processing. The second system is the Regenerable Carbon Dioxide Removal System (RCRS) currently flying on the extended mission duration version of the Shuttle Orbiter. This system uses an amine that is tailored for overboard venting. It was chamber tested as part of its Certification process. Both chamber test series are discussed and performance data presented.