The design of the Nodes, Cupola and Pressurized Mating Adapters (PMAs) has progressed to the point that detailed design is well underway and flight hardware has been fabricated for Node 1. Node 1, PMA 1 and PMA 2 are the first elements of the International Space Station Alpha (ISSA) United States On-Orbit Segment (USOS) launched. The Nodes serve as pressurized passageways between the other elements of ISSA as well as providing pressurized volume for accommodation of subsystem equipment, avionics wiring and fluid utility lines. The Cupola provides external viewing and accommodates a workstation to control the ISSA Space Station Remote Manipulator System (SSRMS). PMAs provide a pressurized connection between the USOS and the Russian Segment as well as the Shuttle. This paper details the current state of the design of these elements.