The increased use of on-board and off-board electronic systems with medium duty and heavy duty trucks and buses presents challenges with compatibility and proper integration. The vehicle architecture is taking shape to establish three areas of computer control-the powertrain, the cab instrument panel, and the cab operations center. The critical element of pursuing proper integration of these systems requires established and clear standards and test methods. Clear roles and responsibilities, a defined system architecture and common test methods are required between subsystem electronic product suppliers and vehicle manufacturers. The electronics integration challenges are presented in the context of the U.S. medium duty and heavy duty automotive industry but have broad applicability to other heavy vehicles and markets worldwide. SAE and ISO forums are needed to address these issues.