Two Cummins B5.9L engines were fueled with 100% biodiesel in excess of 48 months by the Agricultural Engineering Department at the University of Missouri-Columbia. The engines used to power Dodge pickups. The engine lubricating oil was sampled at 1000 mile intervals for analysis. Statistical analysis of the engine lubricating oil indicated that the wear metal levels in the lubricating oil were normal. A reduction in power was noted when the engines were tested using a chassis dynamometer. The 1991 pickup has been driven 110,451 km and the 1992 pickup has been driven approximately 177,022 km. The pickups averaged 6.9 km/L. Engine fuel efficiency and material compatibility issues are addressed in the paper.