The effects of stress in brain material was investigated with experimental and computational idealizations of the head. A water-filled cylinder impacted by a free traveling mass serves to give insight into what could happen to the brain during impact. Under an impact of sufficient velocity, cavitation can occur on the cylinder boundary opposite impact. Limited internal vaporization of the fluid may also occur during severe impact events. Cavitation occurred in these experiments at accelerations greater than 150 g's. Head forms of different sizing will experience an acceleration magnitude inversely proportional to the size difference to produce a similar pressure/cavitation response.