The on-orbit oxygen and nitrogen supply for the United States On-Orbit Segment (USOS) of the International Space Station (ISS) is provided in tanks mounted on the outside of the Airlock module. Gasses are supplied, for distribution to users within the USOS, via pressure regulators in the Airlock. The on-orbit storage can be replenished with gas that is scavenged from the Space Shuttle, or by direct replacement of the tanks.The supply and distribution system are described in this paper. The users of the gasses are identified. The system architecture is presented. Operational considerations are discussed.