Since the environment of vehicle operation is dynamic in nature, dynamic methods should be used in vehicle durability analysis. Due to the constraints in current computer resources, simulation of vehicle durability tests and structural fatigue life assessment need special approaches and efficient CAE tools. The purpose of this paper is to present an efficient methodology and a feasible vehicle dynamic durability analysis process. Two examples of structural durability analysis using transient dynamics are given. The examples show that vehicle stress analysis and fatigue life prediction using dynamic method is now feasible by employing the presented method and process.