The carbon dioxide removal assembly (CDRA) is an essential part of the International Space Station (ISS) environmental control and life support system. As such, this system is required to selectively remove carbon dioxide from the cabin atmosphere, and discharge it overboard to space vacuum. Verification of the many CDRA requirements is divided into analysis, demonstration, inspection, and test methods. This paper focuses on the results of protoflight performance testing conducted on the first deliverable CDRA. The results of this performance testing indicated that the CDRA design exceeded all of the performance requirements.