Excessive impact pressures can develop when an evacuated system is filled with liquid. Such a process is usually highly chaotic, especially when the system geometry is complex. Available computational methods by themselves cannot provide the necessary answers. The International Space Station (ISS) heat exchanger has a complex flow system, and a synthesis of computational and experimental methods was necessary to design the system. The FLOW-NET two-phase flow program was used to determine the range of loss coefficients and the liquid-vapor interface mass and energy transfer that would fit the measured impact pressures. These loss coefficients could then be used to compute the impact pressures for a design configuration similar to the one tested at a range of operating conditions.