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Spacelab mission thermal integration is one of many activities performed at the NASA Marshall Space Flight Center (MSFC). The Spacelab carrier system has been expanded from the original module/pallet system. Thermodynamics and heat transfer as well as fluid mechanics and fluid dynamics are the support areas discussed here. This support incorporates preflight mission analysis in conjunction with real time mission support and postflight mission analysis. This paper summarizes these activities for the Spacelab carrier complement, citing some of the more challenging thermal control designs for which the Center is and has been responsible. Technology advancements, coupled with the ever increasing needs of the payload community and the desire for flexibility to manifest several distinct payload elements on a single mission, has aided in the evolution of a more diverse Spacelab carrier complement.