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Design optimization often relies on computational models, which are subjected to a validation process to ensure their accuracy. Because validation of computer models in the entire design space can be costly, we have previously proposed an approach where design optimization and model validation, are concurrently performed using a sequential approach with variable-size local domains. We used test data and statistical bootstrap methods to size each local domain where the prediction model is considered validated and where design optimization is performed. The method proceeds iteratively until the optimum design is obtained. This method however, requires test data to be available in each local domain along the optimization path. In this paper, we refine our methodology by using polynomial regression to predict the size and shape of a local domain at some steps along the optimization process without using test data.