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In diesel engines the optimization of engine-out emissions, combustion noise and fuel consumption requires the experimental investigation of the effects of different injection strategies as well as of a large number of engine operating variables, such as scheduling of pilot and after pulses, rail pressure, EGR rate and swirl level. Due to the high number of testing conditions involved full factorial approaches are not viable, whereas Design of Experiment techniques have demonstrated to be a valid methodology. However, the results obtained with such techniques require a subsequent critical analysis, so as to investigate the cause and effect relationships between the set of engine operating variables and the combustion process characteristics that affect pollutant formation, noise of combustion and engine efficiency.