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The International Space Station (ISS) requires stores of Oxygen (O2) and Nitrogen (N2) to provide for atmosphere replenishment, direct crew member usage, and payload operations. Currently, supplies of N2/O2 are maintained by transfer from the Space Shuttle. Following Space Shuttle retirement in 2010, an alternate means of resupplying N2/O2 to the ISS is needed. The National Aeronautics and Space Administration (NASA) has determined that the optimal method of supplying the ISS with O2/N2 is using tanks of high pressure N2/O2 carried to the station by a cargo vehicle capable of docking with the ISS. This paper will outline the architecture of the system selected by NASA and will discuss some of the design challenges associated with this use of high pressure oxygen and nitrogen storage in the human spaceflight environment.