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Ever since the first crew arrived at the International Space Station (ISS), archival potable water samples have been collected and returned to the ground for detailed chemical analysis in order to verify that the water supplies onboard are suitable for crew consumption. The Columbia tragedy, unfortunately, has had a dramatic impact on continued ISS operations. A major portion of the ISS water supply had previously consisted of Shuttle-transferred water. The other two remaining sources of potable water, i.e., reclaimed humidity condensate and Russian-launched ground water, are together insufficient to maintain 3-person crews. The Expedition 7 crew launched in April of 2003 was, therefore, reduced from three to two persons. Without the Shuttle, resupply of ISS crews and supplies is dependent entirely on Russian launch vehicles (Soyuz and Progress) with severely limited up and down mass.