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Brain strain secondary to head impact or inertial loading is closely associated with pathologic observations in the brain. The only experimental brain strain dataset under loadings close to traumatic levels was calculated by imposing the experimentally measured motion of markers embedded in the brain to an auxiliary model formed by triad elements (Hardy et al., 2007). However, fidelity of the calculated strain as well as the suitability of using triad elements for three-dimensional (3D) strain estimation remains to be verified. Therefore, this study proposes to use tetrahedron elements as a new approach to estimate the brain strain. Fidelity of this newly-proposed approach along with the previous triad-based approach is evaluated with the aid of three independently-developed finite element (FE) head models by numerically replicating the experimental impacts and strain estimation procedures.

Analysis and validation of current scaling relationships and existing response corridors using animal surrogate test data is valuable, and may lead to the development of new or improved scaling relationships. For this reason, lateral pendulum impact testing of appropriate size cadaveric porcine surrogates of human 3-year-old, 6-year-old, 10-year-old, and 50th percentile male age equivalence, were performed at the thorax and abdomen body regions to compare swine test data to already established human lateral impact response corridors scaled from the 50th percentile human adult male to the pediatric level to establish viability of current scaling laws. Appropriate Porcine Surrogate Equivalents PSE for the human 3-year-old, 6-year-old, 10-year-old, and 50th percentile male, based on whole body mass, were established. A series of lateral impact thorax and abdomen pendulum testing was performed based on previously established scaled lateral impact assessment test protocols.

Relative motion between the brain and skull and brain deformation are biomechanics aspects associated with many types of traumatic brain injury (TBI). Thus far, there is only one experimental endeavor (Hardy et al., 2007) reported brain strain under loading conditions commensurate with levels that were capable of producing injury. Most of the existing finite element (FE) head models are validated against brain-skull relative motion and then used for TBI prediction based on strain metrics. However, the suitability of using a model validated against brain-skull relative motion for strain prediction remains to be determined. To partially address the deficiency of experimental brain deformation data, this study revisits the only existing dynamic experimental brain strain data and updates the original calculations, which reflect incremental strain changes. The brain strain is recomputed by imposing the measured motion of neutral density target (NDT) to the NDT triad model.

An understanding of stiffness characteristics of different body regions, such as thorax, abdomen and pelvis of ES-2re and SID-IIs dummies under controlled laboratory test conditions is essential for development of both compatible performance targets for countermeasures and occupant protection strategies to meet the recently updated FMVSS214, LINCAP and IIHS Dynamic Side Impact Test requirements. The primary purpose of this study is to determine the transfer functions between the ES-2re and SID-IIs dummies for different body regions under identical test conditions using flat rigid wall sled tests. The experimental set-up consists of a flat rigid wall with five instrumented load-wall plates aligned with dummy’s shoulder, thorax, abdomen, pelvis and femur/knee impacting a stationary dummy seated on a rigid low friction seat at a pre-determined velocity.

High-speed biplane x-ray was used to research the kinematics of the small intestine in response to seatbelt loading. Six driver-side 3-point seatbelt simulations were conducted with the lap belt routed superior to the pelvis of six unembalmed human cadavers. Testing was conducted with each cadaver perfused, ventilated, and positioned in a fixed-back configuration with the spine angled 30° from the vertical axis. Four tests were conducted with the cadavers in an inverted position, and two tests were conducted with the cadavers upright. The jejunum was instrumented with radiopaque markers using a minimally-invasive, intraluminal approach without inducing preparation-related damage to the small intestine. Tests were conducted at a target peak lap belt speed of 3 m/s, resulting in peak lap belt loads ranging from 5.4-7.9 kN. Displacement of the radiopaque markers was recorded using high-speed x-ray from two perspectives.

A blast buck (Accelerative Loading Fixture, or ALF) was developed for studying underbody blast events in a laboratory-like setting. It was designed to provide a high-magnitude, high-rate, vertical loading environment for cadaver and dummy testing. It consists of a platform with a reinforcing cage that supports adjustable-height rigid seats for two crew positions. The platform has a heavy frame with a deformable floor insert. Fourteen tests were conducted using fourteen PMHS (post mortem human surrogates) and the Hybrid III ATD (Anthropomorphic Test Device). Tests were conducted at two charge levels: enhanced and mild. The surrogates were tested with and without PPE (Personal Protective Equipment), and in two different postures: nominal (knee angle of 90°) and obtuse (knee angle of 120°). The ALF reproduces damage in the PMHS commensurate with injuries experienced in theater, with the most common damage being to the pelvis and ankle.

A modified Marmarou impact acceleration injury model was developed to study the kinematics of the rat head to quantify traumatic axonal injury (TAI) in the corpus callosum (CC) and brainstem pyramidal tract (Py), to determine injury predictors and to establish injury thresholds for severe TAI. Thirty-one anesthetized male Sprague-Dawley rats (392 ± 13 grams) were impacted using a modified impact acceleration injury device from 2.25 m and 1.25 m heights. Beta-amyloid precursor protein (β-APP) immunocytochemistry was used to assess and quantify axonal changes in CC and Py. Over 600 injury maps in CC and Py were constructed in the 31 impacted rats. TAI distribution along the rostro-caudal direction in CC and Py was determined. Linear and angular responses of the rat head were monitored and measured in vivo with an attached accelerometer and angular rate sensor, and were correlated to TAI data.

The objectives of this study were to examine the response, repeatability, and injury predictive ability of the Hybrid III small-female dummy to static out-of-position (OOP) deployments using a depowered driver-side airbag. Five dummy tests were conducted in two OOP configurations by two different laboratories. The OOP configurations were nose-on-rim (NOR) and chest-on-bag (COB). Four cadaver tests were conducted using unembalmed small-female cadavers and the same airbags used in the dummy tests under similar OOP conditions. One cadaver test was designed to increase airbag loading of the face and neck (a forehead-on-rim, or FOR test). Comparison between the dummy tests of Lab 1 and of Lab 2 indicated the test conditions and results were repeatable. In the cadaver tests no skull fractures or neck injuries occurred. However, all four cadavers had multiple rib fractures.

This study investigated the mechanisms of traumatic rupture of the aorta (TRA). Eight unembalmed human cadavers were tested using various dynamic blunt loading modes. Impacts were conducted using a 32-kg impactor with a 152-mm face, and high-speed seatbelt pretensioners. High-speed biplane x-ray was used to visualize aortic motion within the mediastinum, and to measure deformation of the aorta. An axillary thoracotomy approach was used to access the peri-isthmic region to place radiopaque markers on the aorta. The cadavers were inverted for testing. Clinically relevant TRA was observed in seven of the tests. Peak average longitudinal Lagrange strain was 0.644, with the average peak for all tests being 0.208 ± 0.216. Peak intraluminal pressure of 165 kPa was recorded. Longitudinal stretch of the aorta was found to be a principal component of injury causation. Stretch of the aorta was generated by thoracic deformation, which is required for injury to occur.

Traumatic brain injury (TBI) continues to be a major health problem, with over 500,000 cases per year with a societal cost of approximately $85 billion in the US. Motor vehicle accidents are the leading cause of such injuries. In many cases of TBI widespread disruption of the axons occurs through a process known as diffuse axonal injury (DAI) or traumatic axonal injury (TAI). In the current study, an in vivo TAI model was developed using spinal nerve roots of adult rats. This model was used to determine functional and structural responses of axons to various strains and displacement rates. Fifty-six L5 dorsal nerve roots were each subjected to a predetermined strain range (<10%, 10-20% and >20%) at a specified displacement rate (0.01 mm/sec and 15 mm/sec) only once. Image analysis was used to determine actual strains on the roots during the pull.

Cervical facet joints are implicated as a major source of pain after whiplash injury. The purpose of this study was to investigate the proposed capsule strain injury mechanism of whiplash pain using neurophysiologic methods. Strain thresholds, threshold distribution, saturation strains and afterdischarge responses of capsule neural receptors were characterized in vivo. Goat C5-C6 facet joint capsules were used to identify and characterize capsule receptors in response to controlled uniaxial stretch by recording C6 dorsal rootlet nerve discharge. The joints were stretched at 0.5 mm/sec in a series of tests with 2 mm increments until the capsule ruptured. Ninety-two identified units were responsive to physiologic or noxious stretch while 28 were silent receptors. Among the 50 characterized responsive units, 42 showed low strain thresholds at 10.2±4.6% while 8 had high strain thresholds at 47.2±9.6%.

To date, several lateral impact studies (Bolte et al., 2000, 2003, Marth, 2002 and Compigne et al., 2004) have been performed on the shoulder to determine the response characteristics and injury threshold of the shoulder complex. Our understanding of the biomechanical response and injury tolerance of the shoulder would be improved if the results of these tests were combined. From a larger data base shoulder injury tolerance criteria can be developed as well as corridors for side impact dummies. Data from the study by Marth (2002, 12 tests) was combined with data from the previous studies. Twenty-two low speed tests (4.5 ± 0.7 m/s) and 9 high speed tests (6.7 ± 0.7 m/s) were selected from the combined data for developing corridors. Shoulder force, deflection and T1y acceleration corridors were developed using a minimization of cumulative variance technique.

One of the leading causes of death in automotive crashes is traumatic rupture of the aorta (TRA) or blunt aortic injury (BAI). The risk of fatality is high if an aortic injury is not detected and treated promptly. The objective of this study is to investigate TRA mechanisms using finite element (FE) simulations of reconstructed real-world accidents involving aortic injury. For this application, a case was obtained from the William Lehman Injury Research Center (WLIRC), which is a Crash Injury Research and Engineering Network (CIREN) center. In this selected crash, the case vehicle was struck on the left side with a Principal Direction of Force (PDoF) of 290 degrees. The side structure of the case vehicle crushed a maximum of 0.33 m. The total delta-V was estimated to be 6.2 m/s. The occupant, a 62-year old mid-sized male, was fatally injured. The occupant sustained multiple rib fractures, laceration of the right ventricle, and TRA, among other injuries.

Traumatic rupture of the aorta (TRA) is a leading cause of death in high velocity blunt trauma, particularly motor vehicle accidents. However, little is understood about the mechanisms of TRA and thus, the opportunities to prevent TRA in the motor vehicle environment are compromised. The objective of this study was to determine the relationship between impact response and TRA through analyses of data from cadaver tests that successfully produced TRA in lateral impacts. Seventeen Heidelberg-style side impact sled tests were conducted using unembalmed human cadavers. Three sled speeds were used: 6.7, 9.0, and 10.5 m/s. Three barrier configurations were used: rigid flat wall, rigid wall with a 152-mm offset toward the pelvis, and a flat wall with padding of varying stiffness. Multiple load and acceleration measurements were made on the barrier and cadaver. Potential injury parameters were evaluated and their relative predictive abilities were examined.

Knee injuries represent about 10% of all injuries suffered during car crashes. Efforts to assess the injury risk to the posterior cruciate ligament (PCL) have been based on a study available in the literature (Viano et al., 1978), in which only two of the five knees tested had PCL ruptures. The aims of the current study were to repeat the study with a higher number of samples, study the effects of other soft tissues on knee response, and assess the adequacy of the experimental setup for the identification of a PCL tolerance. A total of 14 knees were tested using a high-speed materials testing machine. Eight were intact knees (with the patella and all the muscular and ligamentous structures), three were PCL-only knees (patella and all the muscular and ligamentous structures other than the PCL removed), and the last three were PCL-only knees with the tibia protected from bending fracture.

Brain tissue architecture consists of a complex network of neurons and vasculature interspersed within a matrix of supporting cells. The role of the relatively suffer blood vessels on the more compliant brain tissues during rapid loading has not been properly investigated. Two 2-D finite element models of the human head were developed. The basic model (Model I) consisted of the skull, dura matter, cerebral spinal fluid (CSF), tentorium, brain tissue and the parasagittal bridging veins. The pia mater was also included but in a simplified form which does not correspond to the convolutions of the brain. In Model II, major branches of the cerebral arteries were added to Model I. Material properties for the brain tissues and vasculature were taken from those reported in the literature. The model was first validated against intracranial pressure and brain/skull relative motion data from cadaveric tests.

The principal focus of this study was the measurement of relative brain motion with respect to the skull using a high-speed, biplanar x-ray system and neutral density targets (NDTs). A suspension fixture was used for testing of inverted, perfused, human cadaver heads. Each specimen was subjected to multiple tests, either struck at rest using a 152-mm-diameter padded impactor face, or stopped against an angled surface from steady-state motion. The impacts were to the frontal and occipital regions. An array of multiple NDTs was implanted in a double-column scheme of 5 and 6 targets, with 10 mm between targets in each column and 80 mm between columns. These columns were implanted in the temporoparietal and occipitoparietal regions. The impacts produced peak resultant accelerations of 10 to 150 g, and peak angular accelerations between 1000 and 8000 rad/s2. For all but one test, the peak angular speeds ranged from 17 to 22 rad/s.

The biomechanical response and injury tolerance of the shoulder in lateral impacts is not well understood. These data are needed to better understand human injury tolerance, validate finite element models and develop biofidelic shoulders in side impact dummies. Seventeen side impact sled tests were performed with unembalmed human cadavers. Data analyzed for this study include T1-Y acceleration, shoulder and thoracic load plate forces, upper sternum x and y accelerations, and struck side acromion x, y and z accelerations. One dimensional deflection at the shoulder level was determined from high-speed film by measuring the distance between a target on T1 and the impacted wall. Force-time response corridors were obtained for tests with 9 m/s pelvic offset, 10.5 m/s pelvic offset, 9 m/s unpadded flat wall, 6.7 m/s unpadded flat wall, 9 m/s soft padding and 9 m/s stiff padding. Maximum shoulder plate forces in unpadded 9 m/s tests (5.5 kN) were larger than in 6.7 m/s tests (3.3 kN).

Relative motion between the brain and skull may explain many types of brain injury such as intracerebral hematomas due to bridging veins rupture [1] and cerebral contusions. However, no experimental methods have been developed to measure the magnitude of this motion. Consequently, relative motion between the brain and skull predicted by analytical tools has never been validated. In this study, radio opaque markers were placed in the skull and neutral density markers were placed in the brain in two vertical columns in the occipitoparietal and temporoparietal regions. A bi-planar, high-speed x-ray system was used to track the motion of these markers. Due to limitations in current technology to record the x-ray image on high-speed video cameras, only low- speed (﹤ 4m/s) impact data were available.

The purpose of this study is to help understand the thoracic response and injury mechanisms in high-energy, limited-stroke, lateral velocity pulse impacts to the human chest wall. To impart such impacts, a linear impactor was developed which had a limited stroke and minimally decreased velocity during impact. The peak impact velocity was 5.6 ± 0.3 m/s. A series of BioSID and cadaver tests were conducted to measure biomechanical response and injury data. The conflicting effects of padding on increased deflection and decreased acceleration were demonstrated in tests with BioSID and cadavers. The results of tests conducted on six cadavers were used to test several proposed injury criteria for side impact. Linear regression was used to correlate each injury criterion to the number of rib fractures. This test methodology captured and supported a contrasting trend of increased chest deflection and decreased TTI when padding was introduced.