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Due to the importance of fulfilling the actual and upcoming environmental legislation, it is an Airbus main target to develop eco-efficient materials. Under consideration of the economical effects, these processes will be implemented into the production line. This paper gives an overview of Airbus and its partners research work, the results obtained within the frame of the European funded, integrated technology demonstrator (ITD) ECO Design for Airframe. This ITD is part of the joint technology initiative Clean Sky. Developments with different grade of maturity from “upstream” as the investigation of materials from renewable recourses up to materials now in use in production as low volatile organic compounds cleaner are under investigation. As a basis for future eco-efficient developments an approach for a quantitative life cycle assessment will be demonstrated.