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During early phases of interior car layout a lot of different aspects have to be considered like crashworthiness, regulations, philosophy of the company etc.. Ergonomic aspects do not always play the most important role in these cases. Since aspects of comfort in cars are getting more and more important in nowadays these aspects should be taken into account very early in the interior car layout process. This paper shows a way to design the interior layout of a car from scratch for a good postural comfort for all anthropometries with the aid of a digital human model (RAMSIS). The novelty of this approach is to use the digital human model to design the interior and not to verify or correct an existing one.