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Technology developers understand the need to optimize technologies for human missions beyond Earth. Greater benefits are achievable when systems that share common interfaces are optimized as an integrated unit, including taking advantage of possible synergies or removing counterproductive efforts at the mission level. Life support, extravehicular activity (EVA), and habitability are three systems that have significant interfaces with the crew, and thus share many common interfaces with each other. Technologies and architectures developed for these systems need to account for the effect that design decisions will have on each of the other systems. Many of these impacts stem from the use of water by the crew and the way that the life support system provides and processes that water. Other resources, especially air-related, can have significant impacts as well.