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Designing a vehicle chassis involves meeting numerous performance requirements related to various domains such as Durability, Crashworthiness and Noise-Vibration-Harshness (NVH) as well as reducing the overall weight of chassis. In conventional Computer Aided Engineering (CAE) process, experts from each domain work independently to improve the design based on their own domain knowledge which may result in sub-optimal or even non-acceptable designs for other domains. In addition, this may lead to increase in weight of chassis and also result in stretching the overall product development time and cost. Use of Multi-Disciplinary Optimization (MDO) approach to tackle these kind of problems is well documented in industry. However, how to effectively formulate an MDO study and how different MDO formulations affect results has not been touched upon in depth.