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The selection of a life support system for a lunar base depends on many interrelated factors, both programmatic and technical. Many factors are identifiable through the application of a systems engineering approach to the lunar base design, in which base and mission requirements are determined. In addition, there is a range of evolving technology options whose cost and maturity affect their potential for inclusion in base designs. Results of ongoing lunar base design are presented with emphasis on the selection of promising approaches for advanced life support systems that decrease overall cost for a single, permanently inhabited lunar base. We identify critical technology areas that inhibit the selection of closed life support systems and propose alternative basing scenarios to alleviate development and operational costs. In particular, we quantify the cost savings associated with establishing a base at a lunar pole in a region of permanent sunlight.