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A simulation-based, system reliability-based design optimization (RBDO) method is presented that can handle problems with multiple failure regions and correlated random variables. Copulas are used to represent the correlation. The method uses a Probabilistic Re-Analysis (PRRA) approach in conjunction with a trust-region optimization approach and local metamodels covering each trust region. PRRA calculates very efficiently the system reliability of a design by performing a single Monte Carlo (MC) simulation per trust region. Although PRRA is based on MC simulation, it calculates “smooth” sensitivity derivatives, allowing therefore, the use of a gradient-based optimizer. The PRRA method is based on importance sampling. It provides accurate results, if the support of the sampling PDF contains the support of the joint PDF of the input random variables. The sequential, trust-region optimization approach satisfies this requirement.