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After launch and activation activities, the Columbus module started its operational life on February 2008 providing resources to the internal and external experiments. In March 2008 two US Payloads were successfully installed into Columbus Module: Microgravity Sciences Glovebox (MSG) and a US payload of the Express rack family, Express Rack 3, carrying the European Modular Cultivation System (EMCS) experiment. They were delivered to the European laboratory from the US laboratory and followed few months later by similar racks; Human Research Facility 1 (HRF1) and HRF2. The following paper provides an overview of US Payloads, giving their main features and experiments run inside Columbus on year 2008. Flight issues, mainly on the hydraulic side are also discussed. Engineering evaluations released to the flight control team, telemetry data, and relevant mathematical models predictions are described providing a background material for the adopted work-around solutions.