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The Shuttle retirement in 2010 will force the ISS program to reconsider how to supply the Station with nitrogen and oxygen for six to ten more years beyond 2010. The major options for post-Shuttle retirement resupply are resupply via transfer vehicle, the use of small Intervehicular Activity (IVA) high pressure tanks, “stockpile” enough gas to support International Space Station (ISS) through end of life, or generate the necessary gases onboard the Station. The method chosen to sustain the ISS will serve as a building block for producing new minimally dependent environmental control and life support systems for future manned missions to the Moon, Mars and beyond.