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Biologically inspired designs have become evident and proved to be innovative and efficacious throughout the history. This paper introduces a bio-inspired design of protective structures that is lightweight and provides outstanding crashworthiness indicators. In the proposed approach, the protective function of the vehicle structure is matched to the protective capabilities of natural structures such as the fruit peel (e.g., pomelo), abdominal armors (e.g., mantis shrimp), bones (e.g., ribcage and woodpecker skull), as well as other natural protective structures with analogous protective functions include skin and cartilage as well as hooves, antlers, and horns, which are tough, resilient, lightweight, and functionally adapted to withstand repetitive high-energy impact loads. This paper illustrates a methodology to integrate designs inspired by nature, Topology optimization, and conventional modeling tools.