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A Human Factors Engineering (HFE) analysis has been involved in the design process of the Mini Pressurized Logistics Module (MPLM) for the International Space Station (ISS) since the beginning, as an integrated part of the design support activities. The support of HFE in the configuration process has been directed towards the optimization of the MPLM design through the analysis and evaluation of all the interfaces occurring in the module - nominal and non-nominal - between the crew, the system and the subsystem equipment. In order to identify and analyze all the crew interfaces occurring inside the module, a systematic approach, involving different disciplines, is necessary. The integration of three different tools such as computer simulation, task analysis and mock-up test activities has been employed as an organic unit, in order to establish a comprehensive collection of useful data.