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This paper presented a part of results from an ongoing project for pedestrian protection, which is carried out at Chalmers University of Technology in Sweden. A validated pedestrian mathematical model was used in this study to simulate vehicle-pedestrian impacts. A large number of simulations have been carried out with various parameters. The injury-related parameters concerning head, chest, pelvis and lower extremities were calculated to evaluate the effect of impact speed and vehicle front structure on the risk of pedestrian injuries. The effect of following vehicle parameters was studied: stiffness of bumper, hood edge, hood top, windscreen frame, and shape of vehicle front structures. A parameter study was conducted by modelling vehicle-pedestrian impacts with various sizes of cars, mini vans, and light trucks. This choice represents the trends of new vehicle fleet and their frequency of involvement in real world accidents.