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This paper considers the design of a life support system for transit to Mars and return to Earth. Because of the extremely high cost of launching mass to Mars, the Mars transit life support system must minimize the amount of oxygen, water, and food transported. The three basic ways to provide life support are to directly supply all oxygen and water, or to recycle them using physicochemical equipment, or to produce them incidentally while growing food using crop plants. Comparing the costs of these three approaches shows that physicochemical recycling of oxygen and water is least costly for a Mars transit mission. The long mission duration also requires that the Mars transit life support system have high reliability and maintainability. Mars transit life support cannot make use of planetary resources or gravity. It should be tested in space on the International Space Station (ISS).

The concept of a general purpose life support system testbed for use in space grew out of considerations arising from the recent consolidation of NASA's Advanced Life Support (ALS) Systems programs. Both the physical-chemical and the biological approaches to regenerative life support will require significant amounts of in-space testing in order to prepare for the final development of systems for human life support. Considerations of the technical requirements and rationales for in-space testing has led to the concept of a common testbed that will allow faster and less expensive long duration tests.