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After several decades of human spaceflight, the community of space-faring nations has accumulated a diverse and sometimes harrowing history of toxicological events that have plagued human space endeavors almost from the very beginning. Some lessons have been learned in ground-based test beds and others were discovered the hard way - when human lives were at stake in space. From such lessons one can build a risk-management framework for toxicological events to minimize the probability of a harmful exposure, while recognizing that we cannot predict all possible events. Space toxicologists have learned that relatively harmless compounds can be converted by air revitalization systems into compounds that cause serious harm to the crew.

The Equivalent System Mass (ESM) metric developed by NASA describes and compares individual system impact on a closed system in terms of a single parameter, mass. The food system of a Mars mission may encompass a large percentage of total mission ESM, and decreasing this ESM would be beneficial. Yeast breads were made using three methods (hand & oven, bread machine, mixer with dough hook attachment & oven). Flat breads were made using four methods (hand & oven, hand & griddle, mixer with dough hook attachment & oven, mixer with dough hook attachment & griddle). Two formulations were used for each bread system (scratch ingredients, commercial mix). ESM was calculated for each of these scenarios. The objective of this study was to compare the ESM of yeast and flat bread production for a Martian surface outpost. Method (equipment) for both types of bread production was demonstrated to be the most significant influence of ESM when one equipment use was assumed.

The International Space Station Waste Collector Subsystem Risk Mitigation Experiment (ISS WCS RME) was flown as the primary (Shuttle) WCS on Space Shuttle flight STS-104 (ISS-7A) in July 2001, to validate new design enhancements. In general, the WCS is utilized for collecting, storing, and compacting fecal & associated personal hygiene waste, in a zero gravity environment. In addition, the WCS collects and transfers urine to the Shuttle waste storage tank. All functions are executed while controlling odors and providing crew comfort. The ISS WCS previously flew on three Shuttle flights as the Extended Duration Orbiter (EDO) WCS, as it was originally designed to support extended duration Space Shuttle flights up to 30 days in length. Soon after its third flight, the Space Shuttle Program decided to no longer require 30 day extended mission duration capability and provided the EDO WCS to the ISS Program.

Conceptual designs for a space suit Personal Life Support Subsystem (PLSS) were developed and assessed to determine if upgrading the system using new, emerging, or projected technologies to fulfill basic functions would result in mass, volume, or performance improvements. Technologies were identified to satisfy each of the functions of the PLSS in three environments (zero-g, Lunar, and Martian) and in three time frames (2006, 2010, and 2020). The viability of candidate technologies was evaluated using evaluation criteria such as safety, technology readiness, and reliability. System concepts (schematics) were developed for combinations of time frame and environment by assigning specific technologies to each of four key functions of the PLSS -- oxygen supply, waste removal, thermal control, and power. The PLSS concepts were evaluated using the ExtraVehicular Activity System Sizing Analysis Tool, software created by NASA to analyze integrated system mass, volume, power and thermal loads.

Debris in the Orbiter crew compartment of early Shuttle missions created crew health concerns and physiological discomfort, and was the cause of some equipment malfunctions. Debris from Orbiters during flight and processing was analyzed, quantized, and evaluated to determine its source. Records were kept on the amount of debris vacuumed by the crew during on-orbit cleaning and the amount found on air-cooled avionics boxes during ground turnaround. After ground turnaround operations at Kennedy Space Center and Palmdale were reviewed from a facility, materials use, and materials control standpoint, the following remedial steps were taken.

Wheat is a candidate crop for the Advanced Life Support (ALS) system, and cereal grains and their products will be included on long-term space missions beyond low earth orbit. While the exact supply scenario has yet to be determined, some type of post-processing of these grains must occur if they are shipped as bulk ingredients or grown on site for use in foods. Understanding the requirements for processing grains in space is essential for incorporating the process into the ALS food system. The ESM metric developed by NASA describes and compares individual system impact on a closed system in terms of a single parameter, mass. The objective of this study was to compare the impact of grain mill type on the ESM of producing yeast and flat breads. Hard red spring wheat berries were ground using a Brabender Quadrumat Jr. or the Kitchen-Aid grain mill attachment (both are proposed post-harvest technologies for the ALS system) to produce white and whole wheat flour, respectively.

NASA-JSC is evaluating planetary mission scenarios where plants will provide the majority of the diet for the crew. The requirements of both plants and crew diet need to be integrated in the development of the final food system. Plant growth has limitations in type and quantity of crops to be produced while diets must meet palatability and nutritional requirements as well as limited processing labor, equipment and power. A plan is presented for the development of a food system based heavily on grown crops. Although the steps taken in the development are applicable to the design of any long duration flight food system. The process begins with the development of a food list, followed by preliminary menu design, nutritional analysis and finally menu testing.