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Pumped two-phase systems using mini or microchannel heat sink evaporators are prime candidates for high heat flux applications due to relatively low pumping power requirements and efficient heat removal in compact designs. A number of challenges exist in the implementation of these systems including: ensuring subcooled liquid to the pump to avoid cavitation, avoiding dry out conditions in heat exchangers that can lead to failures of the components under cooling, and avoiding flow instabilities that can damage components in an integrated system. To reduce risk and cost, modeling and simulation can be employed in the design and development of these complex systems, but such modeling must include the relevant behavior necessary to capture the above dynamic effects.