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Road departures are one of the most deadly crash modes, accounting for nearly one third of all crash fatalities in the US. Lane departure warning (LDW) systems can warn the driver of the departure and lane departure prevention (LDP) systems can steer the vehicle back into the lane. One purpose of these systems is to reduce the quantity of road departure crashes. This paper presents a method to predict the maximum effectiveness of these systems. Thirty-nine (39) real world crashes from the National Automotive Sampling System (NASS) Crashworthiness Data System (CDS) database were reconstructed using pre-crash velocities downloaded for each case from the vehicle event data recorder (EDR). The pre-crash velocities were mapped onto the vehicle crash trajectory. The simulations assumed a warning was delivered when the lead tire crossed the lane line. Each case was simulated twice with driver reaction times of 0.38 s and 1.36 s after which time the driver began steering back toward the road.